Michael Rape's Lab

Key Research Articles

A complete list of publications can be found on Pubmed.
  1. Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion Rodríguez-Pérez F, Manford AG, Pogson A, Ingersoll AJ, Martínez-González B, Rape M Dev Cell. 2021 [pubmed] [pdf]
  2. A Cellular Mechanism to Detect and Alleviate Reductive Stress Manford AG, Rodríguez-Pérez F, Shih KY, Shi Z, Berdan CA, Choe M, Titov DV, Nomura DK, Rape M Cell. 2020 183 46-61 [pubmed] [pdf]
  3. Structural basis for dimerization quality control Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M Nature. 2020 [pubmed] [pdf]
  4. Gene expression and cell identity controlled by anaphase-promoting complex Oh E, Mark KG, Mocciaro A, Watson ER, Prabu JR, Cha DD, Kampmann M, Gamarra N, Zhou CY, Rape M Nature. 2020 579 136-140 [pubmed] [pdf]
  5. Dimerization quality control ensures neuronal development and survival Mena E, Kjolby R, Saxton R, Werner A, Lew B, Boyle J, Harland R, Rape M Science. 2018 eaap8236. [pubmed] [pdf]
  6. Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions Werner A*, Baur R*, Teerikorpi N, Kaya D, Rape M eLife. 2018 7: e35407. [link]
  7. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control Yau RG, Doerner K, Castellanos ER, Haakonsen DL, Werner A, Wang N, Yang XW, Martinez-Martin N, Matsumoto ML, Dixit VM, Rape M Cell. 2017 171: 1-16. [pdf]
  8. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor McGourty C, Akopian D, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M Cell. 2016 167: 525-538. [pubmed] [pdf]
  9. Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation Craney A*, Kelly A*, Jia L, Fedrigo I, Yu H, Rape M PNAS. 2016 113: 5140-5145. [pubmed] [pdf]
  10. Cell-fate determination by ubiquitin-dependent regulation of translation Werner A, Iwasaki S, McGourty C, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia N, Rape M Nature. 2015 525: 523-527. [pubmed] [pdf]
  11. Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate Kelly A*, Wickliffe KE*, Song L*, Fedrigo I, Rape M Mol Cell. 2014 56: 232-245. [pubmed] [pdf]
  12. Enhanced protein degradation by branched ubiquitin chains Meyer HJ, Rape M Cell. 2014 157: 910-921. [pubmed] [pdf]
  13. Microtubule-dependent regulation of mitotic protein degradation Song L, Craney A, Rape M Mol Cell. 2014 53: 179-192. [pubmed] [pdf]
  14. Ubiquitin-dependent regulation of COPII coat size and function Jin L*, Pahuja KB*, Wickliffe KE, Gorur A, Baumgaertel C, Schekman R, Rape M Nature. 2012 482: 495-500. [pubmed] [pdf]
  15. Regulation of ubiquitin chain initiation to control the timing of substrate degradation Williamson A*, Banerjee S*, Zhu X, Philipp I, Iavarone AT, Rape M Mol Cell. 2011 42: 744-757. [pubmed] [pdf]
  16. The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2 Wickliffe KE*, Lorenz S*, Wemmer DE, Kuriyan J, Rape M Cell. 2011 42: 744-757. [pubmed] [pdf]
  17. K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody Matsumoto ML*, Wickliffe KE*, Dong KC, Yu C, Bosanac I, Bustos D, Phu L, Kirkpatrick DS, Hymowitz SG, Rape M, Kelley RF, Dixit VM Mol Cell. 2010 39: 477-84. [pubmed] [pdf]
  18. Regulated degradation of spindle assembly factors by the anaphase-promoting complex Song L, Rape M Mol Cell. 2010 38: 369-382. [pubmed] [pdf]
  19. Identification of a physiological E2 module for the human anaphase-promoting complex Williamson A, Wickliffe KE, Mellone BG, Song L, Karpen GH, Rape M. PNAS. 2009 106: 18213-18218. [pubmed] [pdf]
  20. Mechanism of ubiquitin chain formation by the human anaphase-promoting complex Jin L*, Williamson A*, Banerjee S, Phillip I, Rape M Cell. 2008 133: 653-665. [pubmed] [pdf]
  21. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Stegmeier F*, Rape M*, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ Nature. 2007 446: 876-881. [pubmed] [pdf]
  22. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation Reddy SK*, Rape M*, Margansky WA, Kirschner MW Nature. 2007 446: 921-925. [pubmed] [pdf]

Key Reviews

  1. Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains Haakonsen DL, Rape M Trends Cell Biol. 2019 19: 30102-30103. [pubmed] [pdf]
  2. Principles of Ubiquitin-Dependent Signaling Oh E, Akopian D, Rape M Annual Review of Cell and Developmental Biology. 2018 34: 137-162. [pubmed] [pdf]
  3. Unlocking a dark past Rodríguez-Pérez F, Rape M Elife 2018 [pubmed] [pdf]
  4. The increasing complexity of the ubiquitin code Yau R, Rape M Nat Cell Biol. 2016 18: 579-586. [pubmed] [pdf]
  5. The Colossus of ubiquitylation: decrypting a cellular code Williamson A*, Werner A*, Rape M Mol Cell. 2013 49: 591-600. [pubmed] [pdf]
  6. Dynamic regulation of ubiquitin-dependent cell cycle control Craney A, Rape M. Curr Opin Cell Biol. 2013 25: 704-710. [pubmed] [pdf]
  7. The Ubiquitin Code Komander D, Rape M Annu Rev Biochem. 2012 81: 203-29. [pubmed] [pdf]
  8. Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control Mocciaro A, Rape M J Cell Sci. 2012 125: 255-263. [pubmed] [pdf]
  9. K11-linked ubiquitin chains as novel regulators of cell division Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M Trends Cell Biol. 2011 21: 656-663. [pubmed] [pdf]
  10. Building ubiquitin chains: E2 enzymes at work Ye Y, Rape M Nat Rev Mol Cell Biol. 2009 10: 755-764. [pubmed] [pdf]
* These authors contributed equally.