Michael Rape's Lab

Key Research Articles

A complete list of publications can be found on Pubmed.
  1. Molecular basis of SIFI activity in the integrated stress response Zhi Yang, Diane L. Haakonsen, Michael Heider, Samuel R. Witus, Alex Zelter, Tobias Beschauner, Michael J. MacCoss & Michael Rapé Nature. 2025 [Article]
  2. Reactive oxygen species control protein degradation at the mitochondrial import gate Rachael McMinimy, Andrew G. Manford, Christine L. Gee, Srividya Chandrasekhar, Gergey Alzaem Mousa, Joelle Chuang, Lilian Phu, Karen Y. Shih, Christopher M. Rose, John Kuriyan, Baris Bingol, and Michael Rapé Molecular Cell. 2024 [Article]
  3. Stress response silencing by an E3 ligase mutated in neurodegeneration Diane L. Haakonsen, Michael Heider, Andrew J. Ingersoll, Kayla Vodehnal, Samuel R. Witus, Takeshi Uenaka, Marius Wernig & Michael Rapé Nature. 2024 [Article]
  4. Orphan quality control shapes network dynamics and gene expression Kevin G Mark, SriDurgaDevi Kolla, Jacob D Aguirre, Danielle M Garshott, Stefan Schmitt, Diane L Haakonsen, Christina Xu, Lukas Kater, Georg Kempf, Brenda Martínez-González, David Akopian, Stephanie K See, Nicolas H Thomä, Michael Rapé Cell. 2023 [pubmed] [pdf]
  5. Structural basis and regulation of the reductive stress response Manford AG, Mena EL, Shih KY, Gee CL, McMinimy R, Martínez-González B, Sherriff R, Lew B, Zoltek M, Rodríguez-Pérez F, Woldesenbet M, Kuriyan J, Rape M Cell. 2021 [pubmed] [pdf]
  6. Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion Rodríguez-Pérez F, Manford AG, Pogson A, Ingersoll AJ, Martínez-González B, Rape M Dev Cell. 2021 [pubmed] [pdf]
  7. A Cellular Mechanism to Detect and Alleviate Reductive Stress Manford AG, Rodríguez-Pérez F, Shih KY, Shi Z, Berdan CA, Choe M, Titov DV, Nomura DK, Rape M Cell. 2020 183 46-61 [pubmed] [pdf]
  8. Structural basis for dimerization quality control Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M Nature. 2020 [pubmed] [pdf]
  9. Gene expression and cell identity controlled by anaphase-promoting complex Oh E, Mark KG, Mocciaro A, Watson ER, Prabu JR, Cha DD, Kampmann M, Gamarra N, Zhou CY, Rape M Nature. 2020 579 136-140 [pubmed] [pdf]
  10. Dimerization quality control ensures neuronal development and survival Mena E, Kjolby R, Saxton R, Werner A, Lew B, Boyle J, Harland R, Rape M Science. 2018 eaap8236. [pubmed] [pdf]
  11. Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions Werner A*, Baur R*, Teerikorpi N, Kaya D, Rape M eLife. 2018 7: e35407. [link]
  12. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control Yau RG, Doerner K, Castellanos ER, Haakonsen DL, Werner A, Wang N, Yang XW, Martinez-Martin N, Matsumoto ML, Dixit VM, Rape M Cell. 2017 171: 1-16. [pdf]
  13. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor McGourty C, Akopian D, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M Cell. 2016 167: 525-538. [pubmed] [pdf]
  14. Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation Craney A*, Kelly A*, Jia L, Fedrigo I, Yu H, Rape M PNAS. 2016 113: 5140-5145. [pubmed] [pdf]
  15. Cell-fate determination by ubiquitin-dependent regulation of translation Werner A, Iwasaki S, McGourty C, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia N, Rape M Nature. 2015 525: 523-527. [pubmed] [pdf]
  16. Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate Kelly A*, Wickliffe KE*, Song L*, Fedrigo I, Rape M Mol Cell. 2014 56: 232-245. [pubmed] [pdf]
  17. Enhanced protein degradation by branched ubiquitin chains Meyer HJ, Rape M Cell. 2014 157: 910-921. [pubmed] [pdf]
  18. Microtubule-dependent regulation of mitotic protein degradation Song L, Craney A, Rape M Mol Cell. 2014 53: 179-192. [pubmed] [pdf]
  19. Ubiquitin-dependent regulation of COPII coat size and function Jin L*, Pahuja KB*, Wickliffe KE, Gorur A, Baumgaertel C, Schekman R, Rape M Nature. 2012 482: 495-500. [pubmed] [pdf]
  20. Regulation of ubiquitin chain initiation to control the timing of substrate degradation Williamson A*, Banerjee S*, Zhu X, Philipp I, Iavarone AT, Rape M Mol Cell. 2011 42: 744-757. [pubmed] [pdf]
  21. The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2 Wickliffe KE*, Lorenz S*, Wemmer DE, Kuriyan J, Rape M Cell. 2011 42: 744-757. [pubmed] [pdf]
  22. K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody Matsumoto ML*, Wickliffe KE*, Dong KC, Yu C, Bosanac I, Bustos D, Phu L, Kirkpatrick DS, Hymowitz SG, Rape M, Kelley RF, Dixit VM Mol Cell. 2010 39: 477-84. [pubmed] [pdf]
  23. Regulated degradation of spindle assembly factors by the anaphase-promoting complex Song L, Rape M Mol Cell. 2010 38: 369-382. [pubmed] [pdf]
  24. Identification of a physiological E2 module for the human anaphase-promoting complex Williamson A, Wickliffe KE, Mellone BG, Song L, Karpen GH, Rape M. PNAS. 2009 106: 18213-18218. [pubmed] [pdf]
  25. Mechanism of ubiquitin chain formation by the human anaphase-promoting complex Jin L*, Williamson A*, Banerjee S, Phillip I, Rape M Cell. 2008 133: 653-665. [pubmed] [pdf]
  26. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Stegmeier F*, Rape M*, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ Nature. 2007 446: 876-881. [pubmed] [pdf]
  27. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation Reddy SK*, Rape M*, Margansky WA, Kirschner MW Nature. 2007 446: 921-925. [pubmed] [pdf]

Key Reviews

  1. Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains Haakonsen DL, Rape M Trends Cell Biol. 2019 19: 30102-30103. [pubmed] [pdf]
  2. Principles of Ubiquitin-Dependent Signaling Oh E, Akopian D, Rape M Annual Review of Cell and Developmental Biology. 2018 34: 137-162. [pubmed] [pdf]
  3. Unlocking a dark past Rodríguez-Pérez F, Rape M Elife 2018 [pubmed] [pdf]
  4. The increasing complexity of the ubiquitin code Yau R, Rape M Nat Cell Biol. 2016 18: 579-586. [pubmed] [pdf]
  5. The Colossus of ubiquitylation: decrypting a cellular code Williamson A*, Werner A*, Rape M Mol Cell. 2013 49: 591-600. [pubmed] [pdf]
  6. Dynamic regulation of ubiquitin-dependent cell cycle control Craney A, Rape M. Curr Opin Cell Biol. 2013 25: 704-710. [pubmed] [pdf]
  7. The Ubiquitin Code Komander D, Rape M Annu Rev Biochem. 2012 81: 203-29. [pubmed] [pdf]
  8. Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control Mocciaro A, Rape M J Cell Sci. 2012 125: 255-263. [pubmed] [pdf]
  9. K11-linked ubiquitin chains as novel regulators of cell division Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M Trends Cell Biol. 2011 21: 656-663. [pubmed] [pdf]
  10. Building ubiquitin chains: E2 enzymes at work Ye Y, Rape M Nat Rev Mol Cell Biol. 2009 10: 755-764. [pubmed] [pdf]
* These authors contributed equally.